Conference Schedule

Day1: August 27, 2018

Keynote Forum

Biography

Amyloid beta (Aβ) aggregation is generally associated with Alzheimer’s onset. We have demonstrated that incubation of dopaminergic SH-SY5Y cells with an Aβ peptide fragment (an 11-mer composed of residues 25–35; Aβ (25–35)) results in elevated intracellular nitrosative stress and induces chemical mutation of protein disulfide isomerase (PDI), an endoplasmic reticulum-resident oxidoreductase chaperone. Furthermore, Aβ (25–35) provokes aggregation of both the minor and major biomarkers of Parkinson’s disease, namely, synphilin-1 and α-synuclein, respectively. Importantly, fluorescence studies demonstrate that Aβ (25–35) triggers colocalization of these Parkinsonian biomarkers to form Lewy-body-like aggregates, a key and irreversible milestone in the neurometabolic cascade leading to Parkinson’s disease. In addition, fluorescence assays also reveal direct, aggregation-seeding interactions between Aβ (25–35), PDI and α-synuclein, suggesting neuronal pathogenesis occurs via prion-type cross-transfectivity. These data indicate that the introduction of an Alzheimer’s-associated biomarker in
dopaminergic cells is proliferative, with the percolative effect exercised via dual, independent, Parkinson-pathogenic pathways, one stress-derived and the other prion-like. The results define a
novel molecular roadmap for Parkinsonian transfectivity via an Alzheimeric burden and reveal the involvement of PDI in amyloid beta induced Parkinson’s. We have also explored the ability of
phytochemicals to intercept Aβ-driven Parkinson’s pathogenesis via multiple mechanisms. Results from these studies will be discussed. 

Abstract

Mahesh Narayan has completed his PhD in Biophysics at The Ohio State University and pursued Postdoctoral studies at Cornell University. Currently, he is a Professor of Chemistry at The UTEP and serves on the Editorial Board of PLOS One and Cell Biochemistry and Biophysics. He has published extensively in the areas of protein folding, Parkinson’s disease and pedagogical inroads in chemistry.

Biography

Tazaki Kazue has completed her PhD in Doctor of Science (Geology, Miner­alogy), Tokyo Kyoiku University, Japan. She has worked as Post Doctorate Visiting Fellow at Geological Survey of Canada, ISPG in Calgary, Research Associate at McGill University in Montreal, and Senior Research Associate at The University of Western Ontario, London, Ontario, Canada. She has worked as Associate Professor, at Shimane University, and as Professor, at Kanazawa University, Japan. She was a Visiting Professor at Lac Hong University, in Vietnam and Visiting Professor at the University of Dodoma, Tanzania. She has published more than 500 papers of Environmental Sci­ences. She got many awards from the Geological Society of Japan, Natu­ral Sciences and Engineering Research Council of Canada, Mineralogical Society of Japan, Clay Mineralogical Association of Japan, Ishikawa TV, the Earth Science Award of Chigaku Dantai Kenkyu-Kai, and the award of International Solopetitmist Society Contribution.

 

Abstract

Radioactive vegetation and crops was found in Minami- Soma, Fukushima, Japan, 7 years after the Great East Japan Earthquake, on March 11, 2011. The leak of radioactive 134Cs, 137Cs, 40K, 89Sr, 90Sr and traces of some radionuclides which originated from the Fukushims Daiichi Nuclear Power Plant (FDNPP) accident were found in many kinds of vegetations collected from Minami-Soma, Fukushima, which is 25 km away from FDNPP. We document the mineralogy, the chemistry, and the micro-morphology, using a combination of micro techniques. Quantitative analyses of vegetation and crops, using Ge semiconductor detector and energy-dispersive x-ray fluoresence analyses (ED-XRF), x-ray powder diffraction analyses (XRD), and scanning electron microscopy equipped with energy dispersive spectroscopy (SEM-EDS). The objective of this contribution is to illustrate the ability of various vegitation with minerals and microorganisms which are capable of absorbing both radionuclides and stable isotopes from polluted paddy soils, water and plants in extreme conditions near contaminated Tetsuzan dam in Minami Soma, Fukushima in July 16-18 in 2018. In addition, we found deformed pine tree and pine cone in Minami-Soma City, associated with high radioactivity of fallen leaves and moss. The results obtained here provide evidence of radiation reloaded and ecological impacts of the FDNPP, 7 yeras later.

 

Tracks

  • Fundamentals of Chemistry Education | Biochemistry | Physical Chemistry | Advanced Organic & Inorganic Chemistry | Chemicals & Materials Science | Natural Product Chemistry | Pharma Chemistry | Future Scope of Chemistry
Location:
Speaker

Kazue Tazaki

Kahokugata Lake Institute, Japan

Chair

Speaker

Vaishnavi Parikh

Genus Lifesciences, USA

Co Chair

Biography

Topical formulations are commercially avaiable in several dosage forms such as creams, gels, ointments, foam etc. Optimization of drug content in the dosage form is a critical quality attribue to balance the therapeutic activity of the drug molecule and localized toxicity. This study was therefore designed to screen various formulations for in vitro release of hydroquinone as a model drug from topical bases including different non inonic and anionic gel based formulation in addition to the emulsion based cream formulation with and without different penetration enhancers and compared to cmmercially available product. Vertical Franz diffusion cell based on principle of equilibrium microdialysis, cellulose membrane and donated human skin membrane were utilized to evaluate release form different semisolid formulations. To estimate the drug release patterns, in vitro release data were treated to determine physicochemical parameters, such as steady state flux, diffusion coefficient, permeability coefficient and partition coefficient. The results led to development of a formulation that provided higher release of drug at half the concentration of the marketed product. It was also demonstrated that in case of topical formulations, not the concentration of the drug in the formulation but the nature of the base and layer of formulation in contact with the skin surface presents the drug release.

Abstract

Vaishnavi Parikh has completed her PhD in Pharmaceutics from Philadelphia College of Pharmacy, University of Sciences. She has more than eight years of experience working as a Formulation Scientist in the pharmaceutical industry and currently works as a Manager of product development at Genus Lifesciences Inc. She has published several papers in reputed journals; presented at several international conferences; has been serving as a reviewer on six reputed journals and also an editor for the journal, Insight- Automatic Control.

Biography

Mohd Zobir Hussein has completed his PhD in Physical Chemistry at the University of Reading, UK and Postdoctoral studies from Pennsylvania State
University, USA, University of Southampton, UK, Victoria University of Wellington, New Zealand and University of Western Australia. He has worked
as Professor of Chemistry at University Putra Malaysia (UPM). He has published
more than 300 papers in reputed journals and 6 patents and has been serving as a research fellow at the Institute of Advanced Technology, UPM.

Abstract

Oil palm is currently the world’s main vegetable oil crop due to its high productivity and long life span. However, the yearly harvest was significantly reduced, due to the basal stem rot (BSR) disease which is caused by a fungus,
Ganoderma boninense. In 2010, the incidence of BSR disease was estimated to be about 3.7% with estimated affected areas of around 60,000 hectares. Losses due to Ganoderma disease is estimated to be about USD 0.5 billion. For the control of Ganoderma, integrated sanitation, biological and chemical controls were suggested. In the later, fungicides such as hexaconazole and dazomet were found effective to eradicate Ganoderma inoculum within infected stumps, therefore reducing the spread of Ganoderma. The chemical control can
be further improved via nanotechnology platform through fungicide nanodelivery system (FUNADS), which is expected to prolonging the productive life of the infected palm, reducing the frequency of applying time by controlled release approach and to reduce the toxicity by enclosed it in biodegradable and toxic-free materials. In this work, two fungicides;  hexaconazole and dazomet as the guests were encapsulated into nanomaterials as the hosts (chitosan and layered double hydroxides) for the formation of various FUNADSs using the host-guest supramolecular chemistry approach. The chemical structure of the synthesized nanofungicides was evaluated using x-ray diffraction (XRD), electron microscopy, dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric (TGA/DTG) analyses. The DLS and high resolution transmission electron microscopy (HRTEM) show the FUNADs can be synthesised using various host and guest combinations, and can be turned into the nanoparticles
by adjusting the synthesis parameters. In vitro fungicide release from the FUNADs shows a sustained release manner. Furthermore, in vitro anti-fungal studies of the FUNADs against G. boninense shows better inhibition and lower EC50 value compared to their counterparts, the bare fungicides.

Biography

Mohd Zobir Hussein has completed his PhD in Physical Chemistry at the
University of Reading, UK and Postdoctoral studies from Pennsylvania State
University, USA, University of Southampton, UK, Victoria University of Wellington, New Zealand and University of Western Australia. He has worked
as Professor of Chemistry at University Putra Malaysia (UPM). He has published
more than 300 papers in reputed journals and 6 patents and has been serving as a research fellow at the Institute of Advanced Technology, UPM.

Abstract

Oil palm is currently the world’s main vegetable oil crop due to its high productivity and long life span. However, the yearly harvest was significantly reduced, due to the basal stem rot (BSR) disease which is caused by a fungus,
Ganoderma boninense. In 2010, the incidence of BSR disease was estimated to be about 3.7% with estimated affected areas of around 60,000 hectares. Losses due to Ganoderma disease is estimated to be about USD 0.5 billion. For the control of Ganoderma, integrated sanitation, biological and chemical controls were suggested. In the later, fungicides such as hexaconazole and dazomet were found effective to eradicate Ganoderma inoculum within infected stumps, therefore reducing the spread of Ganoderma. The chemical control can be further improved via nanotechnology platform through fungicide nanodelivery system (FUNADS), which is expected to prolonging the productive life of the infected palm, reducing the frequency of applying time by controlled release approach and to reduce the toxicity by enclosed it in biodegradable and toxic-free materials. In this work, two fungicides; hexaconazole and dazomet as the guests were encapsulated into nanomaterials as the hosts (chitosan and layered double hydroxides) for the formation of various FUNADSs using the host-guest supramolecular chemistry approach. The chemical structure of the synthesized nanofungicides was evaluated using x-ray diffraction (XRD), electron microscopy, dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric (TGA/DTG) analyses. The DLS and high resolution transmission electron microscopy (HRTEM)
show the FUNADs can be synthesised using various host and guest combinations, and can be turned into the nanoparticles by adjusting the synthesis parameters. In vitro fungicide release from the FUNADs shows a sustained release manner. Furthermore, in vitro anti-fungal studies of the FUNADs against G. boninense shows better inhibition and lower EC50 value
compared to their counterparts, the bare fungicides.

Biography

Dr. Md. K. Nazeeruddin received M.Sc. and Ph. D. in inorganic chemistry from Osmania University, Hyderabad, India. He joined as a Lecturer in Deccan College of Engineering and Technology, Osmania University in 1986, and subsequently, moved to Central Salt and Marine Chemicals Research Institute, Bhavnagar, as a Research Associate. He was awarded the Government of IndiaÂ’s fellowship in 1987 for study abroad. In 2014, EPFL awarded him the title of Professor. His current research at EPFL focuses on Dye Sensitized Solar Cells, Perovskite Solar Cells, CO2 reduction, Hydrogen production, and Light-emitting diodes. He has published more than 509 peer-reviewed papers, ten book chapters, and he is inventor/co-inventor of over 50 patents. The high impact of his work has been recognized by invitations to speak at over 130 international conferences, and has been nominated to the OLLA International Scientific Advisory Board. He appeared in the ISI listing of most cited chemists, and has more than 49'000 citations with an h-index of 105. He is teaching "Functional Materials" course at EPFL, and Korea University; directing, and managing several industrial, national, and European Union projects. He was awarded EPFL Excellence prize in 1998 and 2006, Brazilian FAPESP Fellowship in 1999, Japanese Government Science & Technology Agency Fellowship, in 1998, Government of India National Fellowship in 1987-1988. Recently he has been appointed as World Class University (WCU) professor by the Korea University, Jochiwon, Korea (http://dses.korea.ac.kr/eng/sub01_06_2.htm), Adjunct Professor by the King Abdulaziz University, Jeddah, Saudi Arabia and Eminent Professor in Brunei.

Abstract

Organic-inorganic lead halide perovskites have shown impressive power conversion efficiency (PCE) in a range of solar cell architectures.1-2 Despite the multiple ionic compositions that have been reported so far, the presence of organic constituents is an essential element in all the high efficiency formulations, with the methylammonium (MA) and formamidinium (FA) cations being the sole realistic options available to date. In this study, we demonstrate a novel three-dimensional (3D) perovskite with improved material stability as a result of the incorporation of an alternative organic cation, guanidinium, into the MAPbI3 crystal structure.3 The new MA1-xGuaxPbI3 perovskite shows enhanced thermal stability and intrinsically new structural and optoelectronic properties. This allows for stable and high-power conversion efficiencies over 20%, a fundamental step within the perovskite field.

Biography

Linghai Xie has completed his PhD in Macromolecular Chemistry by Fudan University (2006) and visiting researcher studies from Nanyang Technology University (2013). He has worked as professor of Organic Nanochemistry at Nanjing University of Posts and Telecommunications (NJUPT). He has published more than 180 papers in reputed journals and has been serving as a director of the Center for Molecular Systems & Organic Devices (CMSOD) at the Institute of Advanced Materials (IAM).

 

Abstract

 

 

A failure of the quick knowledge transfer of one-pot protocols of a spirofluorene, SFX, to graduate inspired me deep thinking 12 years ago. A mutually four-element principle were described as the matter-energy-information-consciousness (MEIC) = whole cycle that can be also transformed into converse CIEM expression such as motivation-literature-experiencepaper= knowledge or principle-design-engineering-innovation = technology as well as attention-blueprint-execute-existance= being by means of a self-similar self-analysis of mine at background of NJUPT. As a result, I am aware of Daoism and realized the coming era of consciousness after the update intelligence of machine that will completely change the role of chemists in society and universe. In order to keep up with the times, firstly, a hierarchical supercycle from carbon atom to synthetic chemists via artifical intelligent robots have been described that inspired students in the field of chemistry for the integration of knowledge at various area. Secondly, we offer a PhD course (PhDC) with 12 nodes that tell graduates how to discover the knowledge via the process of life-languagephilosophy-science for transferring their attention from hot points of social society to research projects of chemistry area. Thirdly, a training course of operation under the logic decision with a feature of de-principle has been set up for the practice of experiment, characterization, simulation computing as well as the visualization of science data. Finally, center for molecular systems& organic devices (CMSOD) focus on researching one kind of molecular systems and organic devices for robots that play the similar roles of DNA and cells in bio-life. Up to date, it took last ten-year to discover the fluorenoid nano-gridarenes that is a giant family of hierarchical molecular worlds, including various monogrids, multigrids, oligogrids and polygrids as well as smart grids by cloning the objects at macroscopically human-scale world. Prospectively, self-similar four-element MEIC whole theory would make molecular intelligence possible that probably change the belief of human being.

Biography

Nathaniel Ayodeji Omilani has completed his PhD in Science Education from
the University of Ibadan, Ibadan, Oyo State, Nigeria. He currently holds an adjunct position in the Department of Science Mathematics and Technology
Education in the same university. He has supervised many undergraduate and graduate students in the area of chemistry education and elementary science education. He has also taught courses preparing preservice chemistry and elementary science teachers both at the Department of Integrated Science, Federal College of Education, Osiele, Abeokuta and University of Ibadan. He has published 12 papers in reputed journals and has also read more than 9 papers in national and international conferences. His areas of interest and expertise in science/chemistry education are conceptual change and misconceptions in chemistry, integration of information communication
and technology to science and chemistry, development of science teachers’ pedagogical content knowledge and science curriculum (secondary and primary). He is also vast in data analysis in education research and  instrumentation.

Abstract

Understanding stoichiometry is fundamental to chemistry learning just like basic mathematical operation is to mathematics. Students with difficulty in stoichiometry will be unable to solve many problems in various chemistry 
topics. Unfortunately, chemistry students have difficulty in stoichiometry globally. This problem cannot be solved without a thorough analysis and assessment of chemistry teachers’ stoichiometry pedagogical content knowledge (CTSPCK) among other things. This cannot be underscored 
because of the central role teacher’s play in the development of students’ understanding of stoichiometry. To this end, this study carried out an assessment of stoichiometry pedagogical content knowledge (SPCK) of chemistry teachers. The components of SPCK measured in this study were:
knowledge of instructional strategy in stoichiometry (KISS), knowledge of stoichiometry (KS), and the knowledge of students’ understanding in stoichiometry (KSUS). The study further examined the influence of the level of CTSPCK on their students’ achievement in stochiometry. The study adopted an
expo-facto approach to survey, the sample comprised of 19 chemistry teachers selected from senior secondary schools Ijebu-Ode Local Government Area of Ogun State and their students (512). The instruments for data collection were: topic specific pedagogical content knowledge for stoichiometry questionnaire and students’ knowledge of stoichiometry test. The result revealed that the mean score in KS components of CTSPCK was very good ( x=6.05). On the other hand, mean score in the two other essential components of CTSPCK: (KISS; x =3.17) and (KSUS; x =1.21) were very poor. Based on the total
score of teachers’ SPCK, they were categorised as: novice (16), basic (2), developing (1) and experts (0). The study also found out that the level of CTSPCK has a significant influence on students achievement in stoichiometry (F (2,518)=47.11; p<0.05). The main recommendation is an urgent effort to develop CTSPCK most especially KISS and KSUS components.

Biography

Dr Elena Aznar is researcher of the Biomedical Research Center Network
(CIBER) in the area of Bioengineering, Biomaterials and Nanomedicine at Instituto de Reconocimiento Molecular y Desarrollo Tecnológico in Universitat
Politècnica de Valencia. She is co-author of 57 publications (h-index of 26),
has participated in 22 projects and holds 2 patent. Her research interests involve the development of new funtional porous materials. Specially, she works on the developement of gated materials for sensing and drug delivery applications in the biomedical area.

Abstract

Mesoporous materials are defined as porous materials with pores in the range of 2-100 nm. One of the most important class of mesoporous materials are MCM-41 silicabased materials due to their fascinating properties such as
high homogeneous porosity, inertness, thermal stability, the presence of tunable pore sizes, homogeneous pore distribution and the possibility to easily functionalise the external (or internal) surface. These materials can be easily prepared with tailor-made pores of around 2 – 10 nm and show a very large
specific surface area (up to 1200 m2/g), thus having a large load capacity. Additionally, their active functionalization to obtain advanced materials is a timely topic of research that could be very motivating and useful for future researchers and postgraduated students. Anchoring organic molecules,
biomolecules, or supramolecules onto MCM-41 scaffoldings with different chemical natures, sizes, and shapes promotes the development of smart nanodevices that can be applied in certain scientific and technological fields such as catalysis, chemical remediation, drug delivery or sensing. For example,
one attractive approach is to enhance their functionality using supramolecular concepts. It is possible to incorporate in their external surface functional groups or capping ensembles able to open or close at will for advanced controlled-release applications. These systems are constructed for finely tuning
the delivery of chemical or biochemical species from voids of porous supports to a solution in response to predefined stimuli. Such gated materials are composed mainly of two subunits: (i) the porous inorganic support in which a cargo is loaded and (ii) certain molecular or supramolecular entities, generally grafted onto the external surface, which can control mass transport from pores. On the basis of this concept, a large number of imaginative examples have been developed. Their study and the preparation of simple systems could be very significant and appreciated by master students.

Biography

Diabetes mellitus (DM) is the most common cause of diabetic neuropathy (DN). In 2014 the WHO estimated an overall prevalence of 422 million (8.5%). The incidence of diabetic neuropathy approaches 50% in most diabetic populations; its treatment still remains unresolved. The optimal therapy involves: blood glucose level control, anticonvulsants, antidepressants and
opioid administration, though it does not change pathogenic pattern. It has been identified that tumor necrosis factor alpha (TNFα) and renin-angiotensin aldosterone system (RAAS) play a significant role in Type I and Type II diabetes development. The discovery of (pro) renin receptor, (P)RR, has made the renin–angiotensin system (RAS) more multifaceted. After binding to the receptor, renin/prorenin carry out their functions either in angiotensin-II-dependent or - independent pathways that may facilitate the generation of angiotensin-I or activation of second messenger, respectively. The data collected in the present-day indicate the essential pathogenic role of TNFα and
RAAS in the development of T2DM and diabetic neuropathy (DNP) through the activation of Ag II or/and transcription factor MAPK and NFκB an important factors in the control of cell proliferation, differentiation, and apoptosis. In our study we study aliskiren efficacy, that indirectly inhibit the binding of renin to prorenin/renin receptor (P)RR by changing the local conformation of renin. On the other hand, this renin inhibitor significantly decreases the mRNA expression of (P)RR in the kidney cortex of diabetic hypertensive Ren2 rats. Methodology & Theoretical Orientation: The study population consists of 30 individuals diagnosed with diabetes mellitus (DM)
complicated with DNP. The enrolled subjects are divided into two main groups: group I to take aliskiren and group II with the same pathology, proceeding with the treatment without aliskiren but given telmisartan (ARB), for certainty of aliskiren efficacy. At the start of the trial and on completion of the six weeks period TNFa level and C-peptide (for T2DM) will be determined. Findings: Aliskiren improves conditions of T2DM patients with DNP. Namely, the symptoms of neuropathy are reduced, the blood TNFa
level is reduced and C-peptide level is increased. Conclusion & Significance: Our results confirm hypothesis that TNFα and RAAS may play a substantial role in the development and progression of T2DM as well as in pathogenesis of DPN. Aliskiren has modulatory impact on TNFα, as well as on renin/prorenin both pathways. So, we have results for clinical and pharmacological analysis of aliskiren application in diabetic neuropathy.

Abstract

Anna Sh Archvadze has over 8 years’ experience as a Medical Doctor. Over 15
years of experience as a Trainer/Teacher of Medical Sciences. Over 11 years of
experience in health and social project/program development, execution, monitoring and completion and; Over 7 years of experience in International Project Management working for the World Bank Financed Heath projects, Over 5 years’ experience in an assessment of training needs; design and elaboration of training programs, provision of trainings for emergency care medical staff and for healthcare services providers, Over 10 years of experience in supervision of the contract performance with medical institutions, pharmaceutical firms,  governmental and non-governmental organizations.

Biography

Pierre Vogel, PhD degree from the University of Lausanne, 1969 (Prof. H.
Prinzbach). After post-doctoral stays at Yale University, New Haven, USA
(Prof. Martin Saunders) and at Syntex, Mexico-City (Prof. Pierre Crabbé) he
return to Lausanne and become Full Professor of chemistry in 1977, first at
the University of Lausanne, then (2001) at the EPFL. He has authored and
co-authored more than 525 scientific publications and collected more than
12'100 citations.

Abstract

Modern synthesis including asymmetric synthesis, have made fantastic progress during the last 40 years, especially by developing and applying new catalytic reactions. This contributes to render modern technologies more and more sustainable. Synthetic chemists, biochemists and chemical engineers must be able to predict whether a given equilibrium under given conditions will be exergonic or not. For that, thermochemical calculations and statistical thermodynamics are extremely simple, accurate and valuable tools to answer
this question. In the same time one needs to be able to predict the rate of the reactions that will lead to the above equilibrium. Knowledge of reaction mechanisms (how nature transforms matter) and theories of reactivity are the most useful tools to help the molecular scientists. The Vogel-Hook textbook
has been written to help engineers of molecules to approach satisfying answers to the above questions and help scientists to understand the dynamics of molecules. It complements other textbooks of organic chemistry and physical organic chemistry. It also gives a lot of data the molecular scientists will find useful for the invention of new reactions and processes. It presents the most important concepts of the reactivity of organic and organometallic compounds. The book present 8 chapters that are: equilibria and thermochemistry; dditivity rules for thermodynamic parameters and deviations; the rates of chemical reactions; molecular orbital theories; pericyclic reactions; organic photochemistry; catalytic reactions and; transition metal-catalyzed C-C bond forming reactions. A companion workbook gives the literature references and
answers to problems.

Biography

Computational modeling at the molecular or atomic scale can be very useful to obtain a better insight in plasma medicine. Different atomic scale modeling approaches can be used to study the direct interaction of plasma species
with biomolecules or the consequences of these interactions for the biomolecules on a somewhat longer time‐scale. In this work, molecular dynamics simulations are employed to investigate the mechanisms of interactions between reactive oxygen plasma species (H2O2, HOO, HO and O2) and native skin membrane from an atomistic point of view. The result of
dynamic distribution study of reactive oxygen species, i.e. H2O2 and O2 revealed that, these species interact with cholesterol, as one of the primary target in lipid-peroxidation of skinlipid bilayer. Moreover, the permeability of reaction oxygen species, i.e. H2O2, HOO, HO, and O2 along the skin-lipid bilayer is measured by free energy profile. The result of free energy profile shows that, these species in spite of high energy barrier easily travel throughout the membrane. Thereby, breeching the free energy barriers, these reactive oxygen species are able to permeate into the cells, accordingly inflicting oxidative stress, and might lead to apoptosis. Collectively, the insight acquired
from simulations may help in better understanding of the oxidation stress at atomic level. Our simulation result provides fundamental insights into the mechanisms underlying the interactions between reactive oxygen plasma species and the skin-lipid bilayer at the atomic level.

Abstract

Dharmendra Kumar Yadav has completed his PhD in Biological Science from CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India and Postdoctoral studies from Hanyang University Korea and University of Delhi, India. He has worked as Young Scientist at All India Institute of Medical Science Jodhpur, India. He has published more than 40 papers in reputed journals, 03 Book Chapter and US Patent. He is presently working as a Research Professor at Gachon University of Medicine and Science, Incheon city, Korea.

Day2: August 28, 2018

Keynote Forum

Biography

Linghai Xie has completed his PhD in Macromolecular Chemistry and Physics by Fudan University in 2006 and Senior Visiting Scholar studies at Nanyang Technological University (NTU) during 2012-2013. He won the NSFC Award for Excellent Young Scholar in 2013. He has worked as Professor of Organic Hierarchical Chemistry at Nanjing University of Posts & Telecommunications.
He serves as a Director of the Center for Molecular Systems & Organic Devices at the Institute of Advanced Materials. His research contributions include onepot protocol to spirofluorenes (especially spirofluorenexanthene, SFX), Synergistically Molecular Attractor-Repulsor Theory (SMART), nano-grid[n]arenes and molecular multimedia. He has published more than 180 papers in reputed
journals and has been cited by more than 2900.

Abstract

In the past, our researches focus on a multiscale/ hierarchical chemistry of organic devices suffering from a ten-year journey in the molecular world starting from the synthesis of fluorene via supramolecular approaches to intermolecular motifs, nanoscale aggregate, mesoscale orientation film as well as multilayered  heterojunction in order to solve the technology bottleneck in organic/ plastic electronics. Although we developed the organic wide-bandgap semiconductors that cannot be comparable with inorganic performance, a whole node-network and systematic picture of the diverse and multiscale chemical world has been impressed that results in the belief of self-similar epistemology where microscopically molecular worlds could not be mysterious that just resemble human scale society ever since. Our target is to clone all the MEIC aspects of macroscopic worlds at molecular scale that is the effective pathway to activate molecular intelligence and consciousness. Herein, we start from the human-scale window grids as a typical static paradigm that you can see everywhere and that are around you in daily life. Chinese ancient window grids are especially aesthetic besides usefulness for life ever that also record and impress the traditional culture and philosophy of Fang Yuan. They inspired us differentiating from the well-known macrocycles and exploring the unprecedented nano-grid[n]arenes that include a huge family of various unit nanogrids, digrids, multigrids and polygrids via a bottom-up molecular installing nanotechnology (MINT). This kind of hierarchical nano-gridarenes and their nanopolymers will be a diverse platform of covalently multiscale and cross-scale meta-molecules that would be advanced nanomaterials with multiscale precision to face the challenge of plastic electronics and organo-robots in the background of the era of consciousness (EOC) from carbon to robot.

Biography

Dr Vaishnavi Parikh has completed her PhD in Pharmaceutics from Philadelphia College of Pharmacy, University of Sciences. She has more than eight years of experience working as a Formulation Scientist in the pharmaceutical industry and currently works as a Manager of Product development at Genus Lifesciences Inc. She has published several papers in reputed journals; presented at several international conferences; has been serving as a reviewer on six
reputed journals and also an editor for the journal, Insight- Automatic Control.

 

Abstract

Role of polymers is substantial in delivering protein drugs.Delivery of proteins; however, is challenging due to complex interactions including hydrophobic interaction, electrostatic interaction, hydrogen bonding and interaction between adsorbed protein molecules which may lead to loss of protein stability. Several factors that affect these interactions include polymer type, surface charge, pH and ionic strength of the solvent system, presence of competing proteins. It is critical to attain mechanistic understanding of adsorption of proteins at solid/liquid interfaces to deliver the protein in safe and effective form at the site of action. Use of different polymers intended for drug delivery and analytical techniques such as dynamic light scattering spectroscopy, fluorescence spectroscopy and circular dichroism spectroscopy is demonstrated to screen the factors for development of stable dosage form. Evaluation of the changes in secondary and tertiary structure of recombinant human growth hormone (r-hGH) upon adsorption at biodegradable Poly (lactideco-glycolide) PLGA nanoparticles of different hydrophobicity as a function of pH is illustrated to understand the nature of the interactions that govern the adsorption of the protein on the polymer, leading to successful design of sustained delivery systems.

 

 


 

 

Tracks

  • Fundamentals of Chemistry Education | Biochemistry | Advanced Organic & Inorganic Chemistry | Chemicals & Materials Science | Chemical Engineering | Nuclear Chemistry | Pharma Chemistry | Future Scope of Chemistry
Location:
Speaker

Mahesh Narayan

The University of Texas at El Paso, USA

Chair

Speaker

Linghai Xie

Nanjing University of Posts & Telecommunications, China

Co Chair

Biography

Tazaki Kazue has completed her PhD in Doctor of Science (Geology, Mineralogy), Tokyo Kyoiku University, Japan. She has worked as Post Doctorate Visiting Fellow at Geological Survey of Canada, ISPG in Calgary, Research Associate at McGill University in Montreal, and Senior Research Associate at The University of Western Ontario, London, Ontario, Canada. She has worked as Associate Professor, at Shimane University, and as Professor, at
Kanazawa University, Japan. She was a Visiting Professor at Lac Hong  University, in Vietnam and Visiting Professor at the University of Dodoma, Tanzania. She has published more than 500 papers of Environmental Sciences.
She got many awards from the Geological Society of Japan, Natural Sciences
and Engineering Research Council of Canada, Mineralogical Society of Japan, Clay Mineralogical Association of Japan, Ishikawa TV, the Earth Science Award of Chigaku Dantai Kenkyu-Kai, and the award of International
Solopetitmist Society Contribution.

Abstract

On January 2, 1997, the Nakhodka, a Russian tanker loaded with 19,000 kl of C-type heavy oil, was broken up into sections and submerged off Oki Island, Shimane Prefecture, Japan, which yielded serious environmental problems throughout the shores of Hokuriku district. We report the characterization of
C-type heavy oil, 20 years after the Nakhodka oil spill accident, based on observations in the field on January 18 in 2017. We studied the microstructure, mineralogy, chemical composition, and radioactivity associated with the microorganisms in soils contaminated with C-type heavy oil with fishing net and rope, using a combination of microtechniques, analytical data. The fish
gears that had buried in a beach show high concentration of Na, P, S, Cl, Sr, and Pb, which is predominantly indigenous to the spilled C-type heavy oil, whereas Na, Al, Si, P, S, Ca, Fe, and Sr are detected on the fin whale skeletons that has stored in a museum after being collected. X-ray powder diffraction (XRD) of the contaminated soils after 20 years showed consistent with paraffin, graphite and calcite. Many kinds of hydrocarbon-degrading bacteria, such as Micrococcus bacillus and filamentous fungus were found in oilcontaminated soils after 20 years in the coast of Wajima, Ishikawa
Prefecture, Japan. To date, no report has described the results of electron microscopy observations and in this research; such observations are introduced, including the real-life occurrence of bioremediation by hydrocarbon-degrading bacteria, graphite, and paraffin wax. These observations could lead to simple methods of removing C-type heavy oil from the environment.

Biography

Kristian Handoyo Sugiyarto gained his Drs. degree from Yogyakarta State University (UNY), Indonesia in 1978; while appointed to the Academic Staff of UNY (1979), he undertook MSc program in 1984-1987, and then continued to the PhD program in 1989-1992, both at the Department of Inorganic Chemistry, the School of Chemistry, UNSW, Australia, under the supervision of Prof. H A Goodwin. He then undertook a three-six-month Postdoctoral Research, again with Prof. H A Goodwin, 1995-1997. More than 20 international publications dealing with spin-crossover in iron(II) and some education were published in various international journal Scopus indexed, while more than 15 articles published in local-national journals. He also undertook another six-month research in structural study by EXAFS analysis with Prof. Makoto Kurihara at Shizuoka University and with Prof. Saito A at Tokyo Gakugei University, 2002-2003. He also undertook a four-month Academic Recharging Program for doing palladium complex with Prof. Stephen B Colbran at the School of Chemistry, UNSW, Australia, 2009-2010. He has also presented in several international conference in Paris, Rome, UPSI Malaysia, Bangkok Thailand.

 

Abstract

The blue powdered complex of hydrated tris-phenanthroline(II) trifluoroacetate has been isolated by interaction of the corresponding nitrate salt in aqueous solution and slightly excess of bipyridine in ethanol on the addition of an excess of saturated potassium triflate solution and reducing the solvent. The thermogravimetric analysis/differential thermal analysis (TGA/DTA) confirmed the loss of 4.983% mass of the complex corresponding to 2.4 H2O (0.6% error), while atomic absorption spectroscopy (AAS) measurement showed the content of metal to be 6.24% corresponding to the theoretical value of 7.28% (14.28% error) in [Cu(phen)3](CF3COO)2.2.4H2O. Moreover, the analysis of conductance producing the charge ratio of cation by anion to be 2:1, clearly confirms the formula. The magnetic moment, eff, of this complex which was to be 1.95-1.99 BM, indicates that the complex is paramagnetic corresponding to an unpaired electron. UV-Vis spectrum of the complex reveals the only one absorption observed at about 677 nm (14770 cm-1), being associated with the spin allowed transition, 2Eg → 2T2g. The extinction coefficient of 57.8 Lmol-1cm-1 indicates the adoption of octahedral environment in this complex. The infrared spectrum shows absorptions of ligand group which is influenced by the metal-ligand interaction in this complex. The powder XRD analysis of this complex was refined by Rietica-Le Bail method and found to be fit as triclinic crystal system and space group of PI, with parameters of a=10.8985 Å, b=41.0532 Å, c=16.1082 Å, α=98.2720°, β=91.9544°, γ =82.4071°, V=7068.8295Å3, Z=1, Rp=1.83 and Rwp=5.70 Rexp=0.37. The goodness of the fitting, GOF=231.4, was also reflected by the derived Bragg R-Factor of 0.03.

Biography

Dr Cheong Siew Lee has obtained her degree in Pharmacy and PhD in Medicinal Chemistry from the National University of Singapore, Singapore. She has then undergone her postdoctoral training at the Institut für  Pharmakologie, Universität Würzburg, Germany. Currently, she works as a lecturer at the Department of Pharmaceutical Chemistry, International Medical University, Malaysia. Her research interests revolve mainly around structural optimization of new ligands targeting adenosine receptors and dopamine receptors as well as application of computational approaches and pharmacological characterization in the drug design and discovery. Her research work has been published in various top international peer-reviewed journals and book chapters.

Abstract

There are four known subtypes of human adenosine receptors, classified as A1, A2A, A2B and A3 adenosine receptors. They regulate a large array of physiological and pathological functions in the human body. Ligands targeting these adenosine receptor subtypes have been reported to possess therapeutic potential in various diseases. Of note, antagonists of the adenosine receptor subtypes have been shown to be pharmacologically beneficial in modulating Alzheimer’s disease, Parkinson’s disease, inflammatory disorders and cancer. Over the past decades, medicinal chemists have strived to synthesize and characterize new derivatives as human adenosine receptor antagonists with
biological activities of interest. In particular, our research group has been working on the rational design, structural optimization and characterization of new compounds acting as potent human A3 and A2A adenosine receptor antagonists. These compounds have displayed good binding affinities ranging from nanomolar to low micromolar. In this paper, structural modification of new derivatives based on tricyclic scaffold template, and subsequent
transition to the design of new compounds with bicyclic scaffold will be discussed in details. In addition, molecular modeling studies, such as molecular docking and quantitative structureactivity relationship analysis performed in tandem to rationalize the binding affinity profiles obtained from the pharmacological studies will also be elaborated. In brief, the integration of medicinal chemistry, pharmacology and computational approaches
employed has led to the identification of potent and selective human adenosine receptors antagonists.

Biography

Since 2001, The University of Texas at El Paso (UTEP), originally through grants from the National Science Foundation (I-STAR:Integrative Science Success, Teaching, and Retention Program), has developed and enhanced the talent pool of undergraduate students in science and engineering from the Paso
del Norte region of the United States by implementing and honing the concept of peer led team learning (PLTL). Students register for workshops that are co-requisite with lectures in certain introductory science and mathematics courses. These workshops are led by peer leaders, students who have successfully passed the course and are selected for this role. Research has shown that the peer leaders are best able to facilitate the understanding and further refinement of concepts for undergraduates in these gatekeeper courses as opposed to learning only in a lecture setting. These peer leaders are equipped with an eclectic repository of educational techniques which are constantly
refined and expanded through participation in weekly meetings, summer training sessions, travel to educational conferences, and generation and transmission of educational materials. Over the course of UTEP’s PLTL implementation, significant data have been gathered in terms of the impact that this program has had in improving several aspects of Science, Technology, Engineering and Mathematics (STEM) curricula and its absorption. UTEP
was a founding campus in the formation of the Peer-Led Team-Learning International Society as well as the development of a funding mechanism via a living workbook which aid in sustaining the program. The concept and content of the workbooks will be also discussed in this presentation.

Abstract

Mahesh Narayan has completed his PhD in Biophysics at The Ohio State 
University and pursued Postdoctoral studies at Cornell University. Currently,
he is a Professor of Chemistry at The UTEP and serves on the Editorial
Board of PLOS One and Cell Biochemistry and Biophysics. He has published
extensively in the areas of protein folding, Parkinson’s disease and pedagogical
inroads in Chemistry.